This is somewhat interesting, although not too sure how far this can go.
I love the idea of mixing 2D and 3D animation together, it's so Johnny Quest. I have a feeling, though that the trailer is making the show seem too awesome than it actually is. Much like Johnny Quest, which I only watched for the awesome 3D parts. No I kid, but seriously, it could do some good if it has a decent mix of both 3D an 2D animation. That, and a decent plot to the whole thing.
On top of all this, it has an amazing voice cast, including Elijah Wood, Emmanuelle Chriqui, and Mandy Moore, to name a few.
Tron: Uprising debuts toward the end of the year.
Big thanks to SlashFilm for the trailer.